Properties (14)

Id bf8b23be-398b-43d4-97d0-5e597ccdb8cf

Year 2026

Abstract

Cssclasses

purpleRed

Aliases

(Dappen et al., 2026)

Import Date 12-08-2025

Template Version Notes •corrected error in rendering the linked PDF in metadata section • added the tag “noted” to the definition of comments to ignore ( like with the “in another note” tag. this is so that when making notes on chapters of a textbook, i can still export things for manual addition to the obsidian note without having to keep track of what has already been added ). Also moved the version notes to the yaml section • this version added the bookmarks section to auto collect all bookmarks. it also dropped the template auto fill of the initial source field because we never got it working and just overwrote it manually anyway. this version also added logic to handle “in another note” tag. annotations marked with this are completely ignored. used when i have information covered in a bigger note, but still want to highlight that part in text for visual clarity (so as to avoid duplicates of the same information) • running the import more then once will overwrite the file, so do not import again if you have made changes in obsidian that are not in the zotero article.

Dv Authors Emily R. Dappen, Joel I. Berger, Amy M. Belfi, Joel Bruss, Timothy D. Griffiths, Alexander J. Billig, Ariane E. Rhone, Kirill V. Nourski, Daniel Tranel, Brian J. Dlouhy,

Dv Initial Source Misophonia MOCMisophonia

Dv Limitations • Limited testing time and lack of lateralized testing (e.g., monaural misophonia/perception) • No assessments for hyperacusis • Misophonia–amusia interaction not conclusively dissociated (although phenomenologically distinct) • Longitudinal changes not deeply explored

Dv Future Directions • Further case reports or group studies of lesion-induced misophonia • Investigate the specific role of posterior insula in emotion–sound integration • Refined auditory testing to detect lateralized or subtle speech-in-noise deficits

Dv Relevance • gives a case report of a supposed acquisition of Misophonia following brain surgery to treat epilepsy • gives some interesting isni8ghts into some auditory perceptual changes that resulted from the surgery, but I am personally not convinced of the acquisition of Misophonia. they do asses the individual with the DMQ and find them top be Misophonic, but they do not give enough info on how the increased annoyance with finger tapping ( the only described self reported change that is consistent with Misophonia) differs from pre operation.

Checked For Zettle Notes true

Zotero Note Link Generated true

•

A case of acquired amusia and misophonia following right temporal resection

Status:: #status/Bare-bones-review

Metadata

Item Type: #journalArticle
Authors:: Emily R. Dappen, Joel I. Berger, Amy M. Belfi, Joel Bruss, Timothy D. Griffiths, Alexander J. Billig, Ariane E. Rhone, Kirill V. Nourski, Daniel Tranel, Brian J. Dlouhy,
Date:
Date Added: 1764877714000
URL: https://linkinghub.elsevier.com/retrieve/pii/S0378595525003004
DOI: 10.1016/j.heares.2025.109483
Cite Key: dappenCaseAcquiredAmusia2026
Topics: [object Object]
Tags:: #Misophonia, #Bare-bones-review-🦴, #Auditory-Perception, #case-report, #neurosurgery, #posterior-insula, #lesion, #music, #cortex,
PDF Attachments

Abstract


Background/Purpose	Background- • Music perception relies on intact auditory cortical and subcortical structures. • Acquired amusia has been previously linked to lesions in the right superior temporal cortex and associated networks. • Misophonia has been hypothesized to involve anterior insula and motor-related circuits, but acquired cases have not been reported. • Little is known about the effects of lesions to the posterior insula on both music and aversive sound perception. Purpose- • To report and characterize the first documented case of concurrent acquired amusia and misophonia following surgical resection involving the right posterior insula and adjacent auditory and sensory cortices. • To determine the cognitive, perceptual, and emotional profile of auditory dysfunction post-surgery.
Participants/samples	• Single case: 21-year-old right-handed woman • History of drug-resistant epilepsy with seizure onset at age 5 • Normal hearing pre-surgery; left-hemisphere language dominance; 4 years of choir experience • Right posterior insula, posterior superior temporal gyrus, supramarginal gyrus, and inferior parietal sensory cortex were resected
Measures	• Music Perception: BAMP, MBEA • Timing & Beat Perception: BAASTA, Beat Alignment Test • Auditory Imagery & Memory: PIAT, BAIS • Music Reward/Anhedonia: BMRQ • Musical Sophistication: GMSI • Misophonia Severity: DMQ • Speech-in-Noise Perception: ITCP (Iowa Test of Consonant Perception)
Procedures	• Digitally presented music and sound stimuli in a soundproof booth • Multi-talker babble for ITCP • Extensive auditory and music testing 5 months post-resection • Follow-up interviews at 6 and 8 months post-resection
Results	• MBEA: Significant deficits in global score, contour, and interval; normal rhythm and memory • BAMP: Significant deficits in scale and key • DMQ: Symptom severity score = 65 (cutoff = 41); impairment score = 16 (cutoff = 14) – clinically significant misophonia • Beat perception and production (BAASTA, BAT): Lower than average but not significant • Speech-in-noise perception (ITCP): Within normal range despite subjective complaints • Imagery (PIAT, BAIS), Music Reward (BMRQ), and Sophistication (GMSI): Within normal range
Discussion/Limits	Conclusion- • The case illustrates selective deficits in melodic pitch perception, consistent with amusia from right temporal and posterior insular lesions. • Temporal rhythm and beat production were preserved, supporting dual-stream models of melodic and rhythmic processing. • Misophonia symptoms emerged acutely post-surgery, marking the first reported case of acquired misophonia. • The posterior insula may play a previously underappreciated role in regulating emotional responses to sound and auditory social cues.
Limitations::	• Limited testing time and lack of lateralized testing (e.g., monaural misophonia/perception) • No assessments for hyperacusis • Misophonia–amusia interaction not conclusively dissociated (although phenomenologically distinct) • Longitudinal changes not deeply explored
Future Directions::	• Further case reports or group studies of lesion-induced misophonia • Investigate the specific role of posterior insula in emotion–sound integration • Refined auditory testing to detect lateralized or subtle speech-in-noise deficits
Relevance::	• gives a case report of a supposed acquisition of Misophonia following brain surgery to treat epilepsy • gives some interesting isni8ghts into some auditory perceptual changes that resulted from the surgery, but I am personally not convinced of the acquisition of Misophonia. they do asses the individual with the DMQ and find them top be Misophonic, but they do not give enough info on how the increased annoyance with finger tapping ( the only described self reported change that is consistent with Misophonia) differs from pre operation.

Notes

key terms and concepts:

Amusia – A music-specific auditory disorder characterized by deficits in pitch and rhythm perception, affecting one's ability to perceive or produce music accurately.
Misophonia – A condition marked by intense emotional responses (anger, disgust) to specific trigger sounds such as chewing or tapping, typically originating from others.
Posterior Insula – A cortical area implicated in integrating auditory, sensory, and motor processing; linked to both music perception and misophonia.
Dystimbria – Perceptual sound distortion, often described as unpleasant, associated with certain auditory agnosias including amusia.
MBEA – Montreal Battery of Evaluation of Amusia; a standardized battery to assess pitch, rhythm, meter, and memory in music perception.
DMQ – Duke Misophonia Questionnaire; a validated tool for assessing misophonia across symptom and impairment dimensions.
BAASTA – Battery for the Assessment of Auditory Sensorimotor and Timing Abilities; assesses beat production and perception.
GMSI – Goldsmiths Musical Sophistication Index; measures self-reported musical skills and behaviors.

my engagement notes

my questions

my comments

the authors claim that this is a case of acquired misophonia, but do not specify that the individual reported the miso symptoms as new. their was no pre-post operation assessment of misophonia, and given the lack of a mention of the induvial calling the miso symptoms new I am skeptical of the claim.
   - they don't even really set up her miso complaints, they just say she reported symptoms but did not give any details.
   - the closest thing to a Misophonia description is a mention of increased annoyance to finger tapping, which is mid as far as triggers go.
   - they do assess her with the DMQ, and her scores are consistent with Misophonia , I'm just not sure if this is truly an acquired Misophonia or if they jsut found it now because it was highlighted by the other perceptual changes she had as a result of the surgery (page 4)

Bookmarks

reading notes

Selective Musical Preservation

Despite broad musical deficits, patient retained normal perception/enjoyment for specific familiar music (e.g., Morgan Wallen) — potential role for long-term memory templates or style-specific representations in preserving music reward despite perceptual deficits.

Misophonia and Motor Links

Authors hypothesize misophonia may relate to disrupted motor representations in the posterior insula and its connections with sensorimotor areas.

Subjective Recovery Trajectory

Improvement in music perception reported at 6–8 months post-op; misophonia symptoms plateaued but may have been increasingly well-coped-with.

zettelkasten

Dappen 2026 case of acquired Misophonia following brain surgery