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P1-N1 latencies and P1-P2 amplitudes as diagnostic markers of Misophonia

Laag et al. (2025) compared Cortical Auditory Evoked Potentials (CAEPs) in 20 misophonia adults and 20 controls using tone bursts at 500, 1000, 2000, and 4000 Hz, and found earlier P1 and N1 latencies and larger P1 and P2 amplitudes in the misophonia group across all tested frequencies, while P2 and N2 latencies and N1 and N2 amplitudes did not differ. The authors concluded that these CAEPs latency and amplitude differences can serve as diagnostic markers of misophonia, reflecting cortical hyper-responsiveness at early auditory peak generators with intact higher-order processing (Laag et al., 2025).