Case of incidental improvement of Misophonia symptoms via Risperidone

in a 2022 report, Pan et al describe the case of a patient who’s Misophonia symptoms improved following a Risperidone treatment. the patient was a 32-year-old male with ASD, intellectual disability, generalized anxiety disorder, and schizoaffective disorder who was Admitted via the emergency department for acute-onset paranoia and delusions during an outpatient-initiated olanzapine tape. During the course of treatment, Risperidone was administered and incidentally the patient reported reductions in existing Misophonia symptoms at a time when no other pharmacological changes were occurring. this reduced severity is further indicated by a change in his AMISOS-R scores from 31 (sever Misophonia ) to 5 ( sub clinical). although symptoms improved they di not disappear completely, and the authors urge future research to use clinical control trials to evaluate the efficacy of this approach, as the effects reported were not predicted and the mechanism by which the drug could have improved Misophonia symptoms is unknown (Pan et al., 2022).