note

the level and rate of change of cytosolic CA2+ has been proposed as a modulator of rTMS outcomes

• LTP is triggered by acute postsynaptic Ca2+ increases, with gradual increases resulting in LTD.
• this leads some to propose that short trains of iTBS favor strong and transient increases in Ca2+, which promotes LTP induction.
• in contrast, the prolonged Ca2+ increases from cTBS results in the induction of LTD processes

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